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Dr Abdul Ghaffar |
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Ph.D. University of Edinburgh Post-doctoral Fellowship |
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Office: 803 733 3279 Fax: 803 733 3192 E-mail: ghaffar@med.sc.edu |
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| Macrophages are normally capable of efficiently killing infectious agents and subsequently processing their antigens for specific immune responses. The function of these cells can be for specific immune responses but can be altered, however, as a consequence of either drug treatment or disease. Some of these alterations may be detrimental to the host while others may be beneficial. For example, following exposure to certain infectious agents or drugs, macrophages begin to function as suppressor cells and dampen the specific immune responses. Conversely, other physical, chemical and biological agents can render macrophages capable of killing malignant cells, virus infected cells and bacterial and parasitic pathogens. Such up- and down-regulation of macrophage functions alters the overall capacity of the host to resist infections by modifying both specific and nonspecific immune responses. Dr. Ghaffar's research focuses on the effects of chemical and biological immunomodulators on macrophage functions in both specific and non-specific immune responses and resistance to viral infections. | ||
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